Hypercoagulability and Covid-19: literature review
DOI:
https://doi.org/10.29327/2393773.16.1-8Keywords:
Covid-19; hypercoagulability; laboratory tests.Abstract
Introduction: COVID-19 is associated with coagulopathy due to the dysregulated activation of the immune and hemostatic systems. Objective: To compile information on blood coagulation changes associated with COVID-19. Method: A descriptive review was conducted by searching the PubMed database using the terms "blood coagulation," "fibrinolysis," and "laboratory tests," with a filter for clinical studies from 2019 to 2023. COVID-19-associated coagulopathy results from endothelial injury caused by the direct invasion of SARS-CoV-2, leading to microvascular inflammation and complement system activation. The elevation of markers such as fibrinogen and D-dimer reflected this hypercoagulability and correlated with the severity of the disease. Independent predictors for venous thromboembolism (VTE) in the intensive care unit (ICU) included advanced age, male gender, coronary disease, prior myocardial infarction, and elevated D-dimer. Conclusion: COVID-19 is associated with a high incidence of thrombotic complications. The data highlight key parameters that correlated with the severity of COVID-19.
References
ABDEEN, S.; BDEIR, K.; ABU-FANNE, R.; MARAGA, E.; HIGAZI, M.; KHURRAM, N. et al.. Alpha-defensins: risk factor for thrombosis in COVID-19 infection. British Journal of Haematology, v. 194, n. 1, jul. 2021. Disponível em: https://doi.org/10.1111/bjh.17503. Acesso em: 13 maio 2023.
AL-SAMKARI, H.; GUPTA, S.; LEAF, R. K.; WANG, W.; ROSOVSKY, R. P.; BRENNER, S. K. et al.. Thrombosis, bleeding, and the observational effect of early therapeutic anticoagulation on survival in critically ill patients with covid-19. Annals of Internal Medicine, v. 174, n. 5, maio 2021. Disponível em: https://doi.org/10.7326/M20-6739. Acesso em: 13 maio 2023.
AL-SAMKARI, H.; KARP LEAF, R. S.; DZIK, W. H.; CARLSON, J. C. T.; FOGERTY, A. E.; WAHEED, A. et al.. COVID-19 and coagulation: Bleeding and thrombotic manifestations of SARS-CoV-2 infection. Blood, v. 136, n. 4, 23 jul. 2020. Disponível em: https://doi.org/10.1182/BLOOD.2020006520. Acesso em: 13 maio 2023.
ANAKLI, İ.; ÖZCAN, P. E.; POLAT, Ö.; ORHUN, G.; ALAY, G. H.; TUNA, V. et al. Prognostic value of antithrombin levels in COVID-19 patients and impact of fresh frozen plasma treatment: A retrospective study. Turkish Journal of Hematology, v. 38, n. 1, 25 fev. 2021. Disponível em: https://doi.org/10.4274/tjh.galenos.2021.2020.0695. Acesso em: 13 maio 2023.
BILALOGLU, S.; APHINYANAPHONGS, Y.; JONES, S.; ITURRATE, E.; HOCHMAN, J.; BERGER, J. S. Thrombosis in Hospitalized Patients with COVID-19 in a New York City Health System. JAMA - Journal of the American Medical Association, v. 324, n. 8, 20 jul. 2020. Disponível em: https://doi.org/10.1001/jama.2020.13372. Acesso em: 12 maio 2023.
BRANDÃO, S. C. S.; GODOI, E. T. A. M.; RAMOS, J. de O. X.; MELO, L. M. M. P. de; SARINHO, E. S. C. COVID-19 grave: entenda o papel da imunidade, do endotélio e da coagulação na prática clínica. Jornal Vascular Brasileiro, v. 19, n.17 ago. 2020. Disponível em: https://doi.org/10.1590/1677-5449.200131. Acesso em: 9 maio 2023.
CHEN, N.; LI, Y.; FAN, H.; TIAN, A.; YUAN, H.; JIANG, Z. et al.. Analysis of dynamic disturbance in blood coagulation function of patients with Coronavirus Disease 2019: A retrospective observational study. Medicine (United States), v. 99, n. 43, 23 out. 2020. Disponível em: https://doi.org/10.1097/MD.0000000000022635. Acesso em: 13 maio 2023.
CROCHEMORE, T.; PIZA, F. M. T.; RODRIGUES, R. R.; GUERRA, J. C. C.; FERRAZ, L. J. R.; CORRÊA, T. D.. A new era of thromboelastometry. Einstein (São Paulo), São Paulo, v. 15, n. 3, p. 380-385, 12 jun. 2017. Disponível em: http://dx.doi.org/10.1590/s1679-45082017md3130. Acesso em: 5 jul. 2023.
CUKER, A.; PEYVANDI, F. COVID-19: Hypercoagulability. In: LEUNG, L. L.; TIRNAUER, J. S. (orgs.). UpToDate. Waltham, MA: Wolters Kluwer, 2023. Disponível em: https://www.uptodate.com/contents/covid-19-hypercoagulability. Acesso em: 30 jun. 2023.
ELAA, A.; SYRINE, C.; HAIFA, M.; WALID, N.; AMENE, B.; HOUYEM, S. et al. Assessment of Coagulation Profiles by Rotational Thromboelastometry in COVID 19 Patients. Clinical Laboratory, Dallas, v. 68, n. 08/2022, p. 23-40, 2022. Disponível em: http://dx.doi.org/10.7754/clin.lab.2021.211026. Acesso em: 7 jun. 2023.
FEI, Y.; TANG, N.; LIU, H.; CAO, W. Coagulation dysfunction: A hallmark in COVID-19. Archives of Pathology and Laboratory Medicine, v. 144, n. 10, 2020. Disponível em: https://doi.org/10.5858/arpa.2020-0324-SA. Acesso em: 11 maio 2023.
GOLDMAN, L.; SCHAFER, A. I. Goldman-Cecil Medicina. 26o ed. Philadelphia: Guanabara Koogan, 2020.
GOSHUA, G.; PINE, A. B.; MEIZLISH, M. L.; CHANG, C. H.; ZHANG, H.; BAHEL, P. et al. Endotheliopathy in COVID-19-associated coagulopathy: evidence from a single-centre, cross-sectional study. The Lancet Haematology, v. 7, n. 8, ago. 2020. Disponível em: https://doi.org/10.1016/S2352-3026(20)30216-7. Acesso em: 13 maio 2023.
GRANDONE, E.; VIMERCATI, A.; SORRENTINO, F.; COLAIZZO, D.; OSTUNI, A.; CECI, O. et al.. Obstetric outcomes in pregnant COVID-19 women: the imbalance of von Willebrand factor and ADAMTS13 axis. BMC Pregnancy and Childbirth, v. 22, n. 1, 21 fev. 2022. Disponível em: https://doi.org/10.1186/s12884-022-04405-8. Acesso em: 13 maio 2023.
HADID, T.; KAFRI, Z.; AL-KATIB, A. Coagulation and anticoagulation in COVID-19. Blood Reviews, v. 47, n. 1, maio 2021. https://doi.org/10.1016/j.blre.2020.100761. Acessado em: 9 maio 2023.
HALL, J. E.; HALL, M. E. Guyton & Hall - Tratado de Fisiologia Médica. 14o ed. São Paulo: Guanabara Koogan, 2021.
HENRY, B. M.; BENOIT, S. W.; DE OLIVEIRA, M. H. S.; LIPPI, G.; FAVALORO, E. J.; BENOIT, J. L. ADAMTS13 activity to von Willebrand factor antigen ratio predicts acute kidney injury in patients with COVID-19: Evidence of SARS-CoV-2 induced secondary thrombotic microangiopathy. International Journal of Laboratory Hematology, v. 43, n. S1, jul. 2021. Disponível em: https://doi.org/10.1111/ijlh.13415. Acesso em: 13 maio 2023.
HOFFBRAND, V.; STEENSMA, D. P. Hoffbrand’s Essential Haematology. 8o ed. Chichester: Wiley-Blackwell, 2019.
JAMESON, J. L.; FAUCI, A. S.; KASPER, D. L.; HAUSER, S. L.; LONGO, D. L.; LOSCALZO, J. Medicina Interna de Harrison. 20o ed. New York: AMGH Editora Ltda., 2019.
JAVA, A.; APICELLI, A. J.; KATHRYN LISZEWSKI, M.; COLER-REILLY, A.; ATKINSON, J. P.; KIM, A. H. J.; KULKARNI, H. S. The complement system in COVID-19: Friend and foe? JCI Insight, v. 5, n. 15, 18 jun. 2020. Disponível em: https://dx.doi.org/10.1172/jci.insight.140711. Acesso em: 4 maio 2023.
JUNQUEIRA, P. L.; FRANCO, A. C. G.; GONÇALVES, M. de S.; LYRA, I. M. Alterações da coagulação na COVID-19. In: BARRAL-NETTO, M.; BARRETO, M. L.; PINTO JUNIOR, E. P.; ARAGÃO, É. (orgs.). Construção de conhecimento no curso da pandemia de COVID-19: aspectos biomédicos, clínico-assistenciais, epidemiológicos e sociais. 1o ed. Salvador: EDUFBA, 2020. v. 1, p. 108–118.
KICHLOO, A.; DETTLOFF, K.; ALJADAH, M.; ALBOSTA, M.; JAMAL, S.; SINGH, J. et al. COVID-19 and Hypercoagulability: A Review. Clinical and Applied Thrombosis/ Hemostasis, v. 26, n. 9 set. 2020. Disponível em: https://doi.org/10.1177/1076029620962853. Acesso em: 9 maio 2023.
LEENTJENS, J.; HAAPS, T.F.V.; WESSELS, P.F.; SCHTGENS, R.E.G.; MIDDELDORP, S. et al. COVID-19-associated coagulopathy and antithrombotic agents - lessons after 1 year. Lancet Haematol, [S.l.], v. 8, n. 7, p. e524-e533, jul. 2021. Disponível em: https://www.thelancet.com/journals/lanhae/article/PIIS2352- 3026(21)00105-8/fulltext. DOI: 10.1016/S2352-3026(21)00105-8.
LIPCSEY, M.; PERSSON, B.; ERIKSSON, O.; BLOM, A. M.; FROMELL, K.; HULTSTRÖM, M. et al. The Outcome of Critically Ill COVID-19 Patients Is Linked to Thromboinflammation Dominated by the Kallikrein/Kinin System. Frontiers in Immunology, v. 12, n. 22 fev. 2021.
LUO, H. C.; YOU, C. Y.; LU, S. W.; FU, Y. Q. Characteristics of coagulation alteration in patients with COVID-19. Annals of Hematology, v. 100, n. 1, jan. 2021. Disponível em: https://doi.org/10.1007/s00277-020-04305-x. Acesso em: 13 maio 2023.
MEIJDEN, P. E. J. V. D.; HEEMSKERK, J. W. M.. Platelet biology and functions: new concepts and clinical perspectives. Nature Reviews Cardiology, Atlanta, v. 16, n. 3, p. 166-179, mar. 2019. Disponível em: http://dx.doi.org/10.1038/s41569-018-0110-0. Acesso em: 6 maio 2023.
PEREYRA, D.; HEBER, S.; SCHROTTMAIER, W. C.; SANTOL, J.; PIRABE, A.; CHMUCKENSCHLAGER, A. et al. Low-molecular-weight heparin use in coronavirus disease 2019 is associated with curtailed viral persistence: A retrospective multicentre observational study. Cardiovascular Research, v. 117, n. 14, 17 dez. 2021. Disponível em: https://doi.org/10.1093/cvr/cvab308. Acesso em: 13 maio 2023.
RODRIGUES, A; DOMINGUES, T D; JESUS, G N; GARÇÃO, A; RODRIGUES, A R; CORREIA, C J; PEREIRA, C L; CORREIA, D; BELEZA, A; RIBEIRO, J M. COVID- 19-associated Coagulopathy Characterization using Rotational Thromboelastometry in a Prospective, Observational Cohort Study: the hemocov study. Acta Médica Portuguesa, Lisboa, v. 36, n. 7-8, p. 496-505, 3 jul. 2023.
SHI, J.; ZHANG, W.; SANG, L.; QU, Z.; ZHONG, M.; JIANG, L. et al.. Coagulation Dysfunction in Icu Patients with Coronavirus Disease 2019 in Wuhan, China: A Retrospective Observational Study of 75 Fatal Cases. Aging, v. 13, n. 2, 9 dez. 2021. Disponível em: https://doi.org/10.18632/aging.202223. Acesso em: 13 maio 2023.
SILVA, A. R. F. da; OLIVEIRA, B. R. de; BASTOS, B. S.; FRAGA, D. da R.; SOUTO,
K. de O. L.; NUNES, M. E. F. et al. Coagulopatias associadas à infecção por COVID- 19: uma revisão de literatura. Revista Eletrônica Acervo Saúde, v. 13, n. 9, p. 1–7, 2 set. 2021. Disponível em: https://doi.org/10.25248/reas.e8589.2021. Acesso em: 9 maio 2023.
TIEDE, A.; ZIEGER, B.; LISMAN, T.. Acquired bleeding disorders. Haemophilia, Montreal, v. 28, n. 4, p. 68-76, maio 2022. Disponível em:http://dx.doi.org/10.1111/hae.14548. Acesso em: 7 jun. 2023.
ZAGO, M. A.; FALCÃO, R. P.; PASQUINI, R. Tratado de Hematologia. 1o ed. São Paulo: Atheneu, 2013.
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