Anti-hemorrhagic treatments for hemophilia patients undergoing tooth extraction: a review of the literature
DOI:
https://doi.org/10.29327/2393773.17.1-8Keywords:
postoperative care; dental extraction; hemophilia.Abstract
Objective: To present, through a literature review, current anti-hemorrhagic treatments for patients with hemophilia who undergo tooth extractions. Methodology: This is a literature review. The search for articles was carried out in the Pubmed, web of science and scopus databases. Articles in the English language, available in full between the years 2013 and 2024, were included. Searches that duplicated between databases, incomplete publications or that did not fit the scope of the research were excluded. Results: In total, 13 articles were included in the review. The main therapies found were: Desmopressin, Antifibrinolytic agents, Ankaferd Blood Stooper (ABS), Local dressing (TachoComb), Tranexamic acid, Prophylaxis with emicizumab, Thrombin-gelatin (Floseal) and others. Conclusion: There are a series of anti-hemorrhagic treatments for hemophiliac patients undergoing tooth extraction. These therapies vary depending on the specific hemostatic defect, its severity and the type of surgical procedure.
References
ALI, T. et al. Prospective study examining the use of thrombin-gelatin matrix (Floseal) to prevent post dental extraction haemorrhage in patients with inherited bleeding disorders. Int J Oral Maxillofac Surg, v.51, n.3, p. 426-430, 2022. doi: 10.1016/j.ijom.2021.07.018.
BAJKIN, B.; DOUGALL, A. Current state of play regarding dental extractions in patients with haemophilia: Consensus or evidence-based practice? A review of the literature. Haemophilia, v. 26, n, 2, p. 183-199, 2020. doi: 10.1111/hae.13928.
COCERO, N. et al. Autologous plasma rich in glowth factors in the prevention of severe bleeding disorders: a controlled comparison with fibrin glue. Blood Transfus, v. 13, n. 2, p. 287-294, 2015. doi: 10.2450/2014.0124-14.
COPPOLA, A. et al. Treatment for preventing bleeding in people with haemophilia or other congenital bleeding disorders undergoing surgery. Cochrane Database Syst Rev, v. 9, n. 2, p. CD009961, 2015. doi: 10.1002/14651858.CD009961.pub2.
EBBERT, P. T. et al. Emicizumab prophylaxis in patients with haemophilia A with and without inhibitors. Haemophilia, v. 26, n. 1, p. 41-46, 2020. doi: 10.1111/hae.13877.
FRANCHINI, M. et al. Dental procedures in adult patients with hereditary bleeding disorders: 10 years experience in three Italian Hemophilia Centers. Haemophilia, v. 11, n. 5, p. 504-9, 2005. doi: 10.1111/j.1365-2516.2005.01132.x.
HEWSON, I. D.; MAKHMALOAF, P. Management of third molar removal with a single dose of recombinant Factor IX (BeneFIX) and local measures in severe haemophilia B. Aust Dent J, v. 55, n. 3, p. 322-4, 2010. doi: 10.1111/j.1834-7819.2010.01242.x.
HSIEH, J. T. et al. Ten-year study of postoperative complications following dental extractions in patients wits inherited bleeding disorders. Int J Oral Maxillofac Surg, v. 46, n. 9, p. 1147-1150, 2017. doi: 10.1016/j.ijom.2017.04.016.
ANDERSON J. A. et al. Guidance on the dental management of patients with haemophilia and congenital bleeding disorders. Br Dent J, v. 215, n. 10, p. 497-504. doi: 10.1038/sj.bdj.2013.1097.
KATO, T. et al. Congenital factor XI deficiency with multiple tooth extractions (Case report). Exp Ther Med, v. 26, n. 5, p. 509, 2023. doi: 10.3892/etm.2023.12208.
KAZANCIOĞLU, H.O. et al. The Effectiveness of a New Hemostatic Agent (Ankaferd Blood Stopper) for the Control of Bleeding following Tooth Extraction in Hemophilia: A Controlled Clinical Trial. Turk J Haematol, v. 30, n. 1, p. 19-24, 2013. doi: 10.4274/tjh.2012.0036.
LEWANDOWSKI, B. et al. Dental extractions in patients with mild hemophilia A and hemophilia B and von Willebrand disease without clotting factor supplementation. Pol Arch Intern Med, v. 128, n. 7-8, p. 488-490, 2018. doi: 10.20452/pamw.4298.
PEISKER, A. et al. Management of dental extraction in patients with Haemophilia A and B: a report of 58 extractions. Med Oral Patol Oral Cir Bucal, v. 19, n. 1, p. 55-60, 2014. doi: 10.4317/medoral.19191.
RAHMAN, A. et al. Hemophilia treaters' knowledge of risk assessment for prolonged bleeding associated with dental procedures. Spec Care Dentist, v. 39, n. 2, p. 173-179, 2019. doi: 10.1111/scd.12359.
RAMOS EA, et al. Outpatient minor oral surgery in patients with hemophilia: A case series of 23 patients. J Clin Exp Dent, v. 11, n. 2, p. 395-9, 2019. doi: 10.4317/jced.55506.
SHASTRY, S. et al. Hemophilia A: Dental considerations and management. J Int Soc Prev Community Dent, v. 4, n. 3, p. 147-52, 2014. doi: 10.4103/2231-0762.149022.
SUSEN, S. et al. Management of bleeding and invasive procedures in haemophilia A patients with inhibitor treated with emicizumab (Hemlibra®): Proposals from the French network on inherited bleeding disorders (MHEMO), the French Reference Centre on Haemophilia, in collaboration with the French Working Group on Perioperative Haemostasis (GIHP). Haemophilia, v. 25, n. 5, p. 731-737, 2019. doi: 10.1111/hae.13817.
GALEN, K. P. et al. Antifibrinolytic therapy for preventing oral bleeding in patients with haemophilia or Von Willebrand disease undergoing minor oral surgery or dental extractions. Cochrane Database of Systematic Review, v. 24, n. 12, p. CD011385, 2015. doi: 10.1002/14651858.CD011385.pub2.
YAGYUU, T. et al. Peri-operative hemostatic management of tooth extraction in patients with hemophilia A, with and without inhibitors, receiving emicizumab prophylaxis. Haemophilia, v. 29, n. 1, p. 172-179, 2023. doi: 10.1111/hae.14667.
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